Differential Change in mRNA Expression of p75 and Trk Neurotrophin Receptors in Nucleus Gracilis After Spinal Nerve Ligation in the Rat

• Full citation: Goettl VM, Hussain SA, ALzate O. Differential Change in mRNA Expression of p75 and Trk Neurotrophin Receptors in Nucleus Gracilis After Spinal Nerve Litigation in the Rat. Experimental Neurology. 2004;187(2): 533-536.

• Principal Investigator for CMRF Grant Award: Syed-Rehan Hussain

• Conclusions: “The results presented show that in response to nerve ligation FGF-2 is upregulated in dorsal horn reactive astrocytes, suggesting that this growth factor participates in the central responses to peripheral nerve injury. These responses may include events that are associated with regulation of astrocyte proliferation and / or reactivity and, consequently, the ensuing paint pathways. Furthermore, the increase in FGF-2 synthesis observed in DRG neurons suggests neurotrophic functions for this cytokine in response to nerve injury.”