Reciprocal Regulation of Nuclear Factor Kappa B and Its Inhibitor ZAS3 After Peripheral Nerve Injury

Research Projects
Written By Ken Rothermich

  • Full citation: Wu LC, Goettl V, Madiai F, et al. Reciprocal Regulation of Nuclear Factor Kappa B and Its Inhibitor ZAS3 After Peripheral Nerve Injury. BMC Neuroscience. 2006;7(4) 

  • Principal Investigator for CMRF Grant Award: Syed-Rehan Hussain

  • Conclusions: “ZAS3 is expressed in nervous tissues involved in cognitive function and pain modulation. The down-regulation of ZAS3 after peripheral nerve injury may lead to activation of NF-kappaB, allowing Wallerian regeneration and induction of NF-kappaB-dependent gene expression, including pro-inflammatory cytokines. We propose that reciprocal changes in the expression of ZAS3 and NF-kappaB might generate neuropathic pain after peripheral nerve injury.”

Ken Rothermich
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